Trial reportPeerJ2025
Effects of combined exercise training for adults with resistant major depression: a pilot study from the TRACE-RMD project.
Trial report in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05136027 (Exercise Program in Patients With Treatment-resistant Depressive Disorder Compared to Usual Practice), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Program in Patients With Treatment-resistant Depressive Disorder Compared to Usual Practice
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This pilot study analyzed the changes in body composition, cardiorespiratory fitness (CRF), biochemical profile, clinical symptoms, and quality of life (QoL) of adults with resistant major depression (RMD) following 12 weeks of combined exercise training. Methods: Eighteen adults diagnosed with RMD (42.5 ± 9.9 years, 66.7% women) participated in a supervised exercise group (2 days/week). The combined exercise training consisted of low-to-moderate intensity aerobic interval exercise on a bicycle and strength-resistance exercises. All variables were assessed pre- and post-intervention, including clinical symptoms with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Clinical Global Impressions Scale (CGI-S), the Sheehan Disability Scale (SDS), and health-related QoL with the Short Form-36. A symptom-limited cardiopulmonary exercise peak test was performed to evaluate CRF. Results: The baseline results classified the participants as metabolically unhealthy with overweight/obesity, moderate depression, and low CRF and QoL. Following the intervention, there were no significant changes ( Conclusions: A supervised combined exercise program in people with RMD may induce positive and beneficial changes in functionality and clinical and QoL variables, and maintain body composition, CRF, and the biochemical profile. These preliminary results highlight the critical role of supervised exercise, regardless of intensity, in improving clinical symptoms in people with RMD. This study was registered with the International Standard Randomized Controlled Trial Code NCT05136027.
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