Evidence map›Paper›PMID 41282968›Full record

ArticleIranian journal of veterinary research2025

Hepatitis-hydropericardium syndrome in native chickens: A clinicopathological study.

S Alidadi, A Ghaniei, E Cheshmehsangi

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Article in Iranian journal of veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S AlidadiDepartment of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
A GhanieiDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
E CheshmehsangiGraduated from Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatitis-Hydropericardium syndrome (HHS), a significant disease in poultry, is caused by fowl adenoviruses (FAdV). While common in commercial flocks, HHS has not been previously documented in native chicken breeds in Iran. Case description: This case report describes HHS in a small backyard flock of native hens in Mashhad, Iran. The affected birds, three 6-month-old hens, exhibited lethargy for one day prior to death. Findings/treatment and outcome: Post-mortem examination revealed hydronephrosis, splenomegaly, hydropericardium, and hepatic necrosis. Histopathological examination showed significant lesions in the liver, heart, kidney, and spleen. The liver displayed congestion, hemorrhage, hepatocellular degeneration, necrosis, lymphocytic hepatitis, and large basophilic intranuclear inclusion bodies in the affected hepatocytes, confirmed by Lendrum's phloxine-tartrazine method. Cardiac lesions included pericarditis, myocarditis, edema, and myofiber degeneration and necrosis. The spleen exhibited congestion and hemorrhage, while renal tissues showed tubular epithelial cell degeneration and necrosis with inflammation. PCR assay on the liver samples confirmed FAdV serotype 4. Conclusion: These findings show HHS and a FAdV serotype 4 etiology, highlighting the emerging threat of adenoviral diseases to noncommercial poultry settings in Iran.

Indexed as

HepatitisHistopathologyhydropericardium syndromeInclusion bodiesIranNative chicken

Identifiers

PMID41282968
PMCPMC12640158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.