Evidence map›Paper›PMID 41282891›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Diurnal dynamics and psychobiological regulation of cell-free mitochondrial and nuclear DNA in human saliva.

Alexander Behnke, David Shire, Samantha Leonard, Aidan Park, Lauren Petri, Anjali Goyal, Clemens Kirschbaum, Martin Picard, Caroline Trumpff

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alexander BehnkeDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4128-9627
David ShireDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-9866-702X
Samantha LeonardDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0005-3680-0143
Aidan ParkDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0008-5711-6422
Lauren PetriThe Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-0798-3911
Anjali GoyalDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0007-2676-2694
Clemens KirschbaumInstitute of Biopsychology, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany.
Martin PicardDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-2835-0478
Caroline TrumpffDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-7070-5546

Funding

Psychobiological Regulation of Cell-Free Mitochondrial DNA in Human SalivaR21MH123927 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2021 to 2022
$405k
NIMH NIH HHS R21 MH123927
6 · The paper itself

Abstract

Cell-free mitochondrial DNA (cf-mtDNA) has emerged as a dynamic molecular signal responsive to psychological stress and a potential biomarker of stress-related physiological adaptations. While previous work has established the acute stress reactivity of cf-mtDNA in saliva, little is known about its diurnal regulation. In this intensive-sampling study, we characterized the diurnal dynamics of saliva cf-mtDNA across one weekday and one weekend day in healthy adults (

Identifiers

PMID41282891
PMCPMC12633117

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.