Evidence map›Paper›PMID 41282885›Full record

ArticlemedRxiv : the preprint server for health sciences2025

IMPAIRED OLFACTORY FUNCTION IN SUBSTANCE USE DISORDER.

Clara U Raithel, Garrick T Sherman, David H Epstein, Thorsten Kahnt

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Clara U RaithelNational Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224.
Garrick T ShermanNational Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224.
David H EpsteinNational Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224.
Thorsten KahntNational Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224.ORCID 0000-0002-3575-2670

Funding

Neurocomputational mechanisms of learning and decision-making and their disruption in addiction ZIADA000642 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI KAHNT, THORSTEN · 2022 to 2025
$7.2M
Intramural NIH HHS ZIA DA000642
6 · The paper itself

Abstract

The sense of smell plays a key role in guiding motivated behavior, and olfactory function is impaired in clinical populations with dysfunctional approach-avoidance behavior, including major depressive and alcohol use disorder (AUD). However, whether olfactory impairments are also observed in individuals with substance use disorders (SUDs) other than AUD is currently unknown. This study aimed to evaluate the relationship between olfactory function and SUDs. We tested olfaction in 40 individuals with substance use disorders (SUDs) other than AUD using the Sniffin' Sticks odor identification and olfactory threshold tests, versus 112 controls. Group differences were assessed with linear regression models, with diagnosis (SUD vs. controls) as a predictor, controlling for age, sex and smoking. Across a diverse range of substances used, individuals with SUDs had significantly lower

Indexed as

chemical sensesdrug useolfaction

Identifiers

PMID41282885
PMCPMC12633106

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.