ArticlemedRxiv : the preprint server for health sciences2025
Safety and potential benefits of acute intermittent hypoxia in people with chronic traumatic brain injury.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute intermittent hypoxia (AIH) was recently demonstrated to improve motor and cognitive function in several patient populations, including incomplete spinal cord injury, stroke, multiple sclerosis and mild cognitive impairment. Objective: Our clinical trial aimed to establish if AIH can be safely administered in patients with traumatic brain injury (TBI) and to collect preliminary data about its potential efficacy for treating motor, cognitive and affective sequelae of TBI. Methods: Twelve volunteers with chronic TBI underwent four AIH sessions conducted on separate days, in which they were exposed to fifteen 30-60-s hypoxic episodes interspersed with 60-90 s of breathing ambient air. Inspired oxygen (O Results: All participants tolerated the AIH sessions well and were able to complete the entire protocol. No significant improvement in cognition or mood was noted after the AIH intervention. Motor performance gradually improved over the course of the study, but no significant changes in response to TMS were found in corticospinal excitability. Conclusions: AIH dosage as low as 9% O
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