Evidence map›Paper›PMID 41282864›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Chronic prescription opioid use in MS: Associations with adverse outcomes and acute medical service utilization.

Aaron P Turner, Carol Malte, Anne Arewasikporn, Eric J Hawkins, Pradeep Suri, Stephen P Burns, Steven L Leipertz, Jodie K Haselkorn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aaron P TurnerVA Puget Sound Health Care System, Seattle, Washington, USA.
Carol MalteVA Puget Sound Health Care System, Seattle, Washington, USA.
Anne ArewasikpornDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan, USA.
Eric J HawkinsVA Puget Sound Health Care System, Seattle, Washington, USA.
Pradeep SuriVA Puget Sound Health Care System, Seattle, Washington, USA.
Stephen P BurnsVA Puget Sound Health Care System, Seattle, Washington, USA.
Steven L LeipertzVA Puget Sound Health Care System, Seattle, Washington, USA.
Jodie K HaselkornVA Puget Sound Health Care System, Seattle, Washington, USA.

Funding

UW Core Center for Clinical Research of Musculoskeletal ConditionsP30AR072572 · NIAMS · UNIVERSITY OF WASHINGTON · PI JEFFREY G JARVIK, Pradeep Suri · 2017 to 2026
$8.3M
Hypnosis and Meditation for Pain Management in Veterans: Efficacy and MechanismsR01AT008336 · NCCIH · UNIVERSITY OF WASHINGTON · PI JENSEN, MARK P, WILLIAMS, RHONDA · 2014 to 2018
$3.1M
NCCIH NIH HHS R01 AT008336NIAMS NIH HHS P30 AR072572
6 · The paper itself

Abstract

Background: The purpose of this study is to examine whether chronic prescription opioid use in individuals with MS is associated with adverse medical outcomes and acute medical service utilization. Methods: This propensity score-matched, retrospective, cohort study included data from 15,377 Veterans with MS obtained from national VA administrative data. Veterans with filled prescriptions for chronic opioid therapy ( Results: The chronic opioid group had a higher likelihood of a fall (OR Conclusion: Chronic prescription opioid use among Veterans with MS was associated with a higher likelihood of adverse outcome (falls) and higher intensity health care utilization (inpatient admissions and emergency department visits) in the following year. Education regarding MS-specific risks of opioid use should be provided at initial prescription and re-evaluation of risks versus benefits should be conducted regularly.

Indexed as

multiple sclerosisopioidpain

Identifiers

PMID41282864
PMCPMC12635982

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.