Evidence map›Paper›PMID 41282808›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Cannabis use, microbial diversity, and

Donald D Porchia, Yan Wang, Zhi Zhou, Mingkai Chen, Eric C Porges, Ronald A Cohen, Smita Ghare, Shirish Barve, Robert L Cook, Zhigang Li

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Donald D PorchiaDepartment of Biostatistics, University of Florida.
Yan WangDepartment of Epidemiology, University of Florida.
Zhi ZhouDepartment of Epidemiology, University of Florida.
Mingkai ChenDepartment of Biostatistics, University of Florida.
Eric C PorgesDepartment of Clinical and Health Psychology, University of Florida.
Ronald A CohenDepartment of Clinical and Health Psychology, University of Florida.
Smita GhareDepartment of Medicine, University of Louisville.
Shirish BarveDepartment of Medicine, University of Louisville.
Robert L CookDepartment of Epidemiology, University of Florida.
Zhigang LiDepartment of Biostatistics, University of Florida.

Funding

Health outcomes and cognitive effects of marijuana use among persons living with HIV/AIDSR01DA042069 · NIDA · UNIVERSITY OF FLORIDA · PI COOK, ROBERT L · 2017 to 2021
$3.9M
Southern HIV and Alcohol Research Consortium Biomedical Data RepositoryU24AA029959 · NIAAA · UNIVERSITY OF FLORIDA · PI COOK, ROBERT L, WU, SAMUEL S · 2021 to 2025
$2.5M
NIAAA NIH HHS U24 AA029959NIDA NIH HHS R01 DA042069
6 · The paper itself

Abstract

Objectives: People living with HIV (PLWH) frequently experience gastrointestinal symptoms linked to dysbiosis, impaired mucosal barrier integrity, and persistent immune activation. Cannabis is widely used for symptom management by PLWH, but its effects on the gut microbiome are unclear. Methods: We conducted a cross-sectional analysis of 63 PLWH (mean age 59.4 years; 71.4% Black or Hispanic) enrolled in the Marijuana Associated Planning and Long-term Effects study and its microbiome substudy. Participants provided fecal samples for 16S rRNA sequencing. Cannabis use was quantified using a validated Timeline Followback. Alpha diversity was estimated using the Shannon index, beta diversity with Bray-Curtis dissimilarity and PERMANOVA, and genus-level abundance using the IFAA method. Models adjusted for sex, age, and education. Results: Higher cannabis consumption was significantly associated with reduced alpha diversity (β = -1.23, Conclusion: Cannabis consumption in PLWH was associated with lower microbial diversity and reduced

Indexed as

Alpha diversityCannabisDialisterHIVInflammatory bowel disease (IBD)Irritable bowel syndrome (IBS)MarijuanaMicrobiome

Identifiers

PMID41282808
PMCPMC12637788

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.