Evidence map›Paper›PMID 41282784›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Ping-Wu Zhang, Zi-He Wan, Sheng Liu, Jie Wang, Srinivasa Sripathi, Weifeng Li, Junyeop Ahn, Sean Li, Laura Fan, Cynthia A Berlinicke and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ping-Wu ZhangDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Zi-He WanDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Sheng LiuDepartment of Medical and Molecular Genetics, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jie WangDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Srinivasa SripathiHenderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, 75231, USA.
Weifeng LiDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Junyeop AhnDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Sean LiDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Laura FanDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Cynthia A BerlinickeDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Jiang QianDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.
Shannath L MerbsDepartment of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Donald J ZackDepartment of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, MD, 21231, USA.

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
Pangenomic Analysis of DNA Methylation Marks in Glaucoma and Macular DegenerationR01EY020406 · NEI · JOHNS HOPKINS UNIVERSITY · PI MERBS, SHANNATH L · 2009 to 2013
$2.3M
NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY020406
6 · The paper itself

Abstract

Purpose: The human 10q26 locus is a major genetic risk factor for age-related macular degeneration (AMD). Fine mapping by linkage and large-scale genome-wide association studies (GWAS) has narrowed this region to a 30-kb interval encompassing the Methods: Long non-coding RNA (lncRNA) candidates within the Results: We identified and validated a lncRNA, Conclusion: These findings suggest that

Indexed as

Age-related macular degeneration (AMD)ARMS2cigarette smoke extract (CSE)HTRA1HTRA1-AS1human retinainduced pluripotent stem cells (iPSC)long non-coding RNA (lncRNA)paraquatretinal pigment epithelium (PRE)single-nucleotide polymorphism (SNP)

Identifiers

PMID41282784
PMCPMC12637771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.