Evidence map›Paper›PMID 41282737›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Childhood to Adult Neurodevelopment in Gene-Expanded Huntington's Disease (ChANGE-HD) study protocol: A Prospective Longitudinal Neurodevelopmental Study of Huntington's Disease.

Mohit Neema, Nabil Halabi, Peggy C Nopoulos, ChANGE-HD investigators, coordinators, and consultants, Michael Freedberg

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mohit NeemaDepartment of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, IA, USA.ORCID 0009-0003-5047-0166
Nabil HalabiDepartment of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, IA, USA.
Peggy C NopoulosDepartment of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, IA, USA.
ChANGE-HD investigators, coordinators, and consultants
Michael FreedbergDepartment of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-3738-8259

Funding

NINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3M
Longitudinal Assessment of Brain Structure and Function in Juvenile Onset Huntington's DiseaseU01NS055903 · NINDS · UNIVERSITY OF IOWA · PI NOPOULOS, PEGGY C · 2019 to 2025
$17.4M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
NICHD NIH HHS P50 HD103556NINDS NIH HHS U01 NS055903NINDS NIH HHS U24 NS095871
6 · The paper itself

Abstract

Although adult Huntington's disease (HD) studies have significantly advanced our understanding of the course of degeneration, they may underrepresent critical neurodevelopmental aspects of the disease. Significant gaps remain in understanding how mutant huntingtin affects early neurodevelopment, its long-term impact, as well as potential implications for treatment outcomes. The Childhood to Adult Neurodevelopment in Gene-Expanded Huntington's Disease (

Identifiers

PMID41282737
PMCPMC12633616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.