ArticlemedRxiv : the preprint server for health sciences2025
Normal appearing white matter and disability in multiple sclerosis.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Accelerated Brain Aging in Multiple Sclerosis: Microstructural and Metabolic Correlates of the Brain Age Gap.Neurology international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Background and Objectives: Multiple sclerosis (MS) is characterized by lesions and atrophy on conventional MRI, yet these often fail to explain disability. Diffusion MRI (dMRI) detects microstructural injury with diffusion tensor (DTI) and kurtosis imaging (DKI) offering sensitivity, and Standard Model Imaging (SMI) providing biologically interpretable parameters. We evaluated whether these clinically feasible dMRI metrics are associated with disability beyond volumetric and lesion measures, and whether effects arise from normal-appearing white matter (NAWM). Methods: This cross-sectional study included MS patients who underwent 3T MRI including T1- and T2-weighted and a ~7-minute multi-shell dMRI protocol. Brain volumes (gray matter, white matter, thalamus) and lesion load were derived using FreeSurfer and Icobrain. Diffusion metrics included radial diffusivity (RD) from DTI, radial kurtosis (RK) from DKI, intra-axonal water fraction ( Results: Ninety-two patients (68 women; mean age 48, range 24-73; median disease duration 14 years; EDSS 3.0, range 0-8.5) were included. dMRI revealed widespread associations with all clinical measures that persisted after lesion exclusion, implicating NAWM. Functional outcomes were tract-specific: 9HPT correlated with corticospinal tract and optic radiations (RD ρ=0.45; RK ρ=-0.44; Discussion: dMRI detects NAWM injury underlying functional impairment beyond atrophy and lesions. SMI adds specificity (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.