Evidence map›Paper›PMID 41282668›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Healthcare System Resilience and Adaptation: A Six-Year Analysis of Heart Failure Care in the Veterans Affairs System.

Nicholas K Brownell, Moira Inkelas, Lillian Chen, Mei Leng, Anthony Anh Quoc Doan, Nicholas Jackson, Priscilla Hsue, Michael Ong, Elizabeth Yano, Gregg C Fonarow and 1 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nicholas K BrownellDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.ORCID 0000-0001-8156-0808
Moira InkelasDepartment of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA.ORCID 0000-0003-1963-2430
Lillian ChenDivision of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Mei LengDivision of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Anthony Anh Quoc DoanDivision of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Nicholas JacksonDivision of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.ORCID 0000-0002-9515-5050
Priscilla HsueDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Michael OngDepartment of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA.
Elizabeth YanoDepartment of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA.ORCID 0000-0002-9385-0025
Gregg C FonarowDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.ORCID 0000-0002-3192-8093
Boback ZiaeianDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.ORCID 0000-0001-9787-3649

Funding

CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
NHLBI NIH HHS T32 HL007895
6 · The paper itself

Abstract

Background: The Veterans Health Administration (VA) healthcare system cares for almost 200,000 Veterans with heart failure with reduced ejection fraction (HFrEF). It is not known how this population fared regarding continuity of care quality measures and access over the past 6 years, including the COVID-19 pandemic and its aftermath. This study aimed to evaluate temporal trends in heart failure care delivery and identify prognostic factors for clinical outcomes for Veterans with HFrEF from 1/1/2019-12/31/2024. Methods: An interrupted time series analysis examined care patterns across pre-pandemic, early COVID, and late COVID periods using linear regression models with monthly fixed effects. Survival analysis of Veterans with HFrEF identified prognostic factors for mortality and hospitalization. Results: The study included 210,535 individuals (mean age 73.1; 2.2% women; mean ejection fraction 32.5%). HFrEF medication prescriptions were maintained or improved, with upward trends for most medications in the early COVID period and all medications in the late COVID period (range: 0.1-0.9 percentage point increase per 6-week period, compared to pre-COVID baseline), yet with significant treatment gaps for all medication classes by study end. The onset of COVID led to a 2-4-fold increase in telehealth utilization (primary care: 18.2 percentage points, 95% CI: 14.7 to 21.6; cardiology: 8.6 percentage points, 95% CI: 7.4 to 9.8). There was a sustained 45% relative decrease in all-cause hospitalization and 40% relative decrease in heart failure hospitalization, but a sustained 20% increase in mortality. Cumulative survival was 56.1% at 6 years. Conclusions: HFrEF medication rates were generally sustained or improved but well below optimal levels for Veterans with HFrEF. Telehealth replaced some in-person care early in the pandemic. Despite these changes, this high-risk population experienced a sustained decrease in hospitalizations and increase in mortality.

Indexed as

Delivery of health careHealth services researchHeart failureInterrupted time series analysisSurvival analysisVeterans health

Identifiers

PMID41282668
PMCPMC12633086

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.