Evidence map›Paper›PMID 41282650›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Multivariate Host-Pathogen Interactions Driving Heterogeneous Viral Shedding and CD8

Nicole Bruce, Jordan J A Weaver, Cailan Jeynes-Smith, Fatemeh Beigmohammadi, Solène Hegarty-Cremer, Amanda P Smith, Morgan Craig, Amber M Smith

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole BruceDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN USA.
Jordan J A WeaverDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN USA.
Cailan Jeynes-SmithDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN USA.
Fatemeh BeigmohammadiSainte-Justine University Hospital Research Centre, Montréal, Québec, Canada.
Solène Hegarty-CremerSainte-Justine University Hospital Research Centre, Montréal, Québec, Canada.
Amanda P SmithDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN USA.
Morgan CraigSainte-Justine University Hospital Research Centre, Montréal, Québec, Canada.ORCID 0000-0003-4852-4770
Amber M SmithDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN USA.ORCID 0000-0002-7092-6904

Funding

Virtual Patient Cohorts to Illuminate Immunologic Drivers of Influenza SeverityR01AI170115 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SMITH, AMBER M · 2022 to 2025
$2.8M
Predictive Modeling of Influenza-Pneumococcal CoinfectionR01AI139088 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SMITH, AMBER M · 2018 to 2022
$2.1M
NIAID NIH HHS R01 AI139088NIAID NIH HHS R01 AI170115
6 · The paper itself

Abstract

Influenza virus infections vary widely in severity, with human challenge studies revealing substantial heterogeneity in viral shedding and immune responses. Yet, the mechanistic basis of this variability remains unresolved. Here, we applied a multivariate mechanistic modeling framework to determine how variation in viral replication and CD8

Identifiers

PMID41282650
PMCPMC12637797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.