Evidence map›Paper›PMID 41282633›Full record

ArticleFrontiers in pharmacology2025

Bioassay-guided isolation of sesamin and fargesin from the hydroalcoholic stem extract of

Ningthoujam Indrajit Singh, Chayan Mukherjee, Jerina Soibam, Wangkheimayum Marjit Singh, Naresh Chandra Bal, Sunil Kumar Raghav, Chingakham Brajakishor Singh

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ningthoujam Indrajit Singh *Plant Bioresources Division, Institute of Bioresources and Sustainable Development (IBSD), Imphal, Manipur, India.
Chayan Mukherjee *Institute of Life Sciences, Bhubaneswar, Odisha, India.
Jerina SoibamDepartment of Chemistry, Ghanapriya Women's College, Dhanamanjuri University, Imphal, Manipur, India.
Wangkheimayum Marjit SinghDepartment of Chemistry, Ghanapriya Women's College, Dhanamanjuri University, Imphal, Manipur, India.
Naresh Chandra BalSchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Bhubaneswar, Odisha, India.
Sunil Kumar RaghavInstitute of Life Sciences, Bhubaneswar, Odisha, India.
Chingakham Brajakishor SinghPlant Bioresources Division, Institute of Bioresources and Sustainable Development (IBSD), Imphal, Manipur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Method: Sequential fractions were prepared from the hydromethanolic stem extract of Results: Sequential ethyl acetate fraction showed the highest protein anti-denaturation and membrane stabilization activities. Afterward, sesamin and fargesin were isolated from the sequential ethyl acetate fraction. Both of them showed activity against IL12 production by conventional type 1 dendritic cells. Moreover, fargesin significantly inhibited the expression of CD80. Conclusion: The results identified bioactive compounds with potential against the pro-inflammatory dendritic cells for the first time. The findings justified the traditional use of

Indexed as

CD80fargesinintracellular IL12p40/70sesaminZanthoxylum armatum DC.

Identifiers

PMID41282633
PMCPMC12634626

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.