ArticleFrontiers in pharmacology2025
Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Severe adverse drug reactions (SADRs) pose significant challenges to pharmacotherapy. Machine learning (ML) models hold promise in providing reliable solutions for predicting SADRs. This study is designed to pinpoint the independent risk factors contributing to SADRs through the application of ML techniques, thus constructing a predictive model for SADRs applicable in real-world clinical settings. Methods: This retrospective dual-center cohort study analyzed adverse drug reaction (ADR) cases reported in two Chinese tertiary medical centers from 2014 to 2022. Per the World Health Organization - Uppsala Monitoring Centre severity criteria, cases were classified as SADRs or common ADRs. Independent predictors were identified via univariate and multivariate logistic regression (LR). A random partitioning of the data set resulted in a 75% training set and a 25% test set. The performance of three ML algorithms, including LR, Random Forest and Gradient Boosting Machine, was compared. A nomogram was constructed, model performance was measured by the area under the receiver operating characteristic curve (AUC), concordance index (C index), Hosmer-Lemeshow test (H-L test), Decision Curve Analysis (DCA), and Clinical Impact Curve (CIC). Results: A total of 508 SADRs were identified. The AUC values of LR model demonstrates the highest predictability among the three ML models. The AUC was 0.707 in the test set and the AUC in the training set was 0.689. A nomogram was established based on the LR model and evaluated. The C-index was 0.714 in the test set and the AUC in the training set was 0.713; The H-L test produced a chi-square value of 9.769 ( Conclusion: This study established a predictive nomogram for SADRs based on LR through comparative analysis of three ML approaches. The developed nomogram enables clinically meaningful risk stratification for SADRs, facilitating prophylactic surveillance of high-risk populations.
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