ArticleFrontiers in pharmacology2025
Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the clinical efficacy of remifentanil mild sedation versus propofol deep sedation for anesthesia during painless gastroscopy. Methods: A total of 980 patients undergoing painless gastroscopy at our hospital's endoscopy center from January to May 2025 were enrolled and randomly divided into a control group (490 cases, propofol-etomidate mixture intravenous injection) and an observation group (490 cases, remifentanil intravenous injection) using a computer-generated random sequence with sealed envelope allocation. Intraoperative vital sign changes, complication rates, time to ambulation, anesthetic dosage, and patient satisfaction were compared between the two groups. Results: The overall complication rate in the observation group was 0.6%, significantly lower than 64% in the control group (P < 0.05). 76.3% of patients in the observation group experienced intraoperative blood pressure and heart rate fluctuations, compared to 78.6% in the control group, with no significant difference (P > 0.05). The observation group demonstrated significantly shorter ambulation time (17 ± 1.8 vs. 25 ± 3.6 min, P < 0.01) and higher satisfaction rates (patients: 92% vs. 94.4%; clinicians: 98% vs. 95%, P < 0.05) than the control group. Multivariate logistic regression analysis showed that remifentanil use was an independent factor for reducing complications (OR = 0.12, 95%CI:0.05-0.28, P < 0.001). Conclusion: Remifentanil intravenous injection combined with lidocaine gel for mild sedation anesthesia effectively alleviates discomfort during gastroscopy. Compared with propofol-based deep sedation, it demonstrates a lower complication rate and higher safety.
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