Evidence map›Paper›PMID 41282591›Full record

ArticleFrontiers in pharmacology2025

Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus.

Marion Brollo, Stanislas Grassin-Delyle, Camille Roquencourt, Elisabeth Longchampt, Isabelle Miguet-Besson, Matthieu Glorion, Hélène Salvator, Philippe Devillier

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Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Marion BrolloLaboratory of Research in Respiratory Pharmacology, VIM Suresnes, UMR-0892, Foch Hospital, Suresnes, France.
Stanislas Grassin-DelyleFaculty of Health Sciences Simone Veil, University of Versailles Saint Quentin en Yvelines, Paris Saclay University, Montigny-leBretonneux, France.
Camille RoquencourtLaboratory of Research in Respiratory Pharmacology, VIM Suresnes, UMR-0892, Foch Hospital, Suresnes, France.
Elisabeth LongchamptPathology Department, Foch Hospital, Suresnes, France.
Isabelle Miguet-BessonPathology Department, Foch Hospital, Suresnes, France.
Matthieu GlorionLaboratory of Research in Respiratory Pharmacology, VIM Suresnes, UMR-0892, Foch Hospital, Suresnes, France.
Hélène SalvatorLaboratory of Research in Respiratory Pharmacology, VIM Suresnes, UMR-0892, Foch Hospital, Suresnes, France.
Philippe DevillierLaboratory of Research in Respiratory Pharmacology, VIM Suresnes, UMR-0892, Foch Hospital, Suresnes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The role of somatostatin (SST) in the modulation of cholinergic neurotransmission has not been explored previously in human bronchi. We investigated the effects of SST, selective agonists of the five SST receptors SSTR, and octreotide (a SSTR Methods: Human bronchial rings (n = 326) were obtained from 32 patients undergoing surgery for lung carcinoma. 5 Hz EFS (biphasic pulse width: 1 ms; constant current: 320 mA for 10 s) induced contractions that reached about ∼30% of the maximum contraction caused by 40 Hz EFS. Bronchial rings were stimulated for 240 min in the presence or absence of various concentrations of SST, octreotide, and selective agonists of each of the five SSTR receptors. Furthermore, the tissue and cellular locations of each of the five types of SSTR was determined by immunohistochemistry. Results: SST, octreotide, and the SSTR agonists did not change the resting tone or the contractions produced by the cumulative addition of acetylcholine (10 Conclusion: The present study provided new data on the location of SSTR in the human lung: notably, all types of receptor were found in the parasympathetic nerve ganglia of the bronchial wall. We suggest that the activation of prejunctional SSTR

Indexed as

bronchuscholinergic nervecontractionhumanimmunohistochemistrylungsomatostatin receptors

Identifiers

PMID41282591
PMCPMC12631201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.