ArticleBiochemistry and biophysics reports2025
Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Breast cancer (BC) is a leading cause of cancer mortality worldwide. Ferroptosis, an unique form of iron-dependent cell death, has emerged as a promising therapeutic target to overcome drug resistance. This study aimed to identify key ferroptosis-related genes and their regulatory pathways that are dysregulated in BC. Methods: Through a systems biology approach, we analyzed gene expression data from two independent GEO datasets. We identified differentially expressed genes (DEGs) in tumor versus normal tissues and intersected them with a curated database of ferroptosis regulators to define a high-confidence list of Ferroptosis-related DEGs (FeffDEGs). Subsequently, we performed functional enrichment, protein-protein interaction (PPI) network analysis to identify hub genes, and explored their potential regulatory miRNAs and transcription factors (TFs). Results: We identified 73 FeffDEGs significantly enriched in pathways related to oxidative stress and lipid metabolism. Seven hub genes were pinpointed, including the upregulated oncogene Conclusions: Our findings highlight that hub genes like
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