Evidence map›Paper›PMID 41282532›Full record

ArticleRegenerative biomaterials2025

Tissue-engineered liver using 3D-printed silk fibroin scaffolds loaded with stem cells for the treatment of acute liver injury.

Xiaonan Shi, Xuan Wu, Daxu Zhang, Feng Du, Jingjing Hu, Zhanbo Wang, Yutong Liu, Sanduo Li, Shuo Zhao, Weilong Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaonan ShiThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Xuan WuThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Daxu ZhangFaculty and Institute of Hepato-Pancreato-Biliary Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, PR China.
Feng DuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Diseases, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing 100050, PR China.
Jingjing HuThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Zhanbo WangDepartment of Pathology, Chinese PLA General Hospital, Beijing, 100853, PR China.
Yutong LiuThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Sanduo LiSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, PR China.
Shuo ZhaoThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Weilong LiThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Shujun YeThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Jingyi WangThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.
Xiaojiao LiuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China.
Yaopeng ZhangState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China.ORCID https://orcid.org/0000-0002-7175-6150
Li YanThe Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver tissue engineering offers a promising therapeutic strategy for acute liver injury (ALI). Although traditional biomaterial scaffolds exhibit favorable biocompatibility, they still face limitations in the construction of precise structures and the design of functional properties, making it difficult to fully meet the requirements for the repair of specific organs and tissues. In recent years, 3D-printed silk fibroin (3D-SF) scaffolds have demonstrated broad application prospects in tissue and organ repair owing to their excellent biological properties. In this study, a silk fibroin (SF) solution was used as bioink to successfully fabricate 3D-SF scaffolds with fine microarchitectures and mechanical properties matching those of ALI-affected liver tissue, employing a 4K-resolution micro-nano 3D printer integrated with digital light processing technology.

Indexed as

3D printingacute liver injuryadipose-derived stem cellsliver tissue engineeringtissue engineering

Identifiers

PMID41282532
PMCPMC12639544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.