Evidence map›Paper›PMID 41282501›Full record

ArticleIDCases2025

Atypical presentation of leptospirosis as aseptic meningitis in an immunocompromised patient: Impact of rituximab on recovery and prolonged inflammatory response.

Shifa Karatela, Swechchha Silwal, Bhargav P Patel, Julio C Mendez, Sammer M Elwasila

Abstract readCase Reports
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shifa KaratelaMayo Clinic, Jacksonville, FL, USA.
Swechchha SilwalMayo Clinic, Jacksonville, FL, USA.
Bhargav P PatelMayo Clinic, Jacksonville, FL, USA.
Julio C MendezMayo Clinic, Jacksonville, FL, USA.
Sammer M ElwasilaMayo Clinic, Jacksonville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptospirosis is a zoonotic spirochaetal infection with a broad clinical spectrum, ranging from mild anicteric illness to severe systemic disease. Central nervous system (CNS) involvement, particularly aseptic meningitis, is an underrecognized and diagnostically challenging manifestation, especially when isolated from systemic signs. We report a case of a 43-year-old male with a history of CNS demyelinating disease, treated with rituximab, who presented with a one-month history of recurrent fever, headache, and painful lower extremity nodules. He also experienced unintentional weight loss. After a thorough infectious workup, cerebrospinal fluid (CSF) analysis, including broad-range PCR and the Karius test, confirmed the diagnosis of leptospirosis caused by

Indexed as

Aseptic meningitisBroad-range PCRImmunocompromised hostLeptospira noguchiiLeptospirosisNeuroleptospirosis

Identifiers

PMID41282501
PMCPMC12630097

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.