Evidence map›Paper›PMID 41282460›Full record

ArticleForensic sciences research2025

Systematic analysis of full-sibling identification by adding genetic markers and reference relatives.

Qianqian Kong, Shubo Wen, Zhenmin Zhao, Man Chen, Weijie Teng, Liqin Chen, Ran Li, Hongyu Sun, Xiling Liu

Abstract read
In one paragraph

Article in Forensic sciences research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Qianqian KongShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, China.
Shubo WenShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, China.
Zhenmin ZhaoShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, China.
Man ChenShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, China.
Weijie TengShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, China.
Liqin ChenSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
Ran LiFaculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Hongyu SunFaculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-5926-4495
Xiling LiuShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, China.ORCID https://orcid.org/0000-0003-1318-6150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Full-sibling (FS) identification is a crucial aspect of kinship analysis. However, current FS identification methods need to be more accurate and effective for routine FS identification. In this study, the optimal cut-off values for FS identification by incorporating both the identical by state (IBS) and likelihood ratio (LR) methods under four different levels of error rates were assessed. The corresponding sensitivity, specificity, accuracy, and effectiveness were calculated for different numbers of short tandem repeats (STRs), ranging from 19 to 55. The identified cut-off values were validated using authentic pedigrees from the Han population in East China. It was determined that the cut-off values derived from the IBS method and LR method with an error rate below 0.01% were dependable and practical. The study also explored the impact of half-sibling relationships and the inclusion of reference relatives in FS identification. Currently, an updated technical specification for FS identification in China was released, serving as a valuable resource for FS testing in forensic applications.

Indexed as

forensic geneticsforensic sciencesfull-sibling identificationidentical by state (IBS)kinship testinglikelihood ratio (LR)short tandem repeat (STR)

Identifiers

PMID41282460
PMCPMC12632192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.