Evidence map›Paper›PMID 41282409›Full record

ArticleBioactive materials2026

Magnetic-topological multistage synergy: Anisotropic ovalbumin scaffolds loaded with magnetically-responsive neural cells for long-distance peripheral nerve regeneration.

Wenchao Guan, Yaqiong Liu, Mingzhu Jia, Lele Wang, Hongxia Gao, Shaolan Sun, Yuqing Shang, Huoyun Shen, Jian Yang, Nana Jin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wenchao GuanJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Yaqiong LiuJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Mingzhu JiaJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Lele WangJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Hongxia GaoJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Shaolan SunJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Yuqing ShangJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Huoyun ShenJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Jian YangDepartment of Neurosurgery, People's Hospital of Deyang City, Sichuan Clinical Research Center for Neurological Diseases, Deyang, 618000, China.
Nana JinInstitute for Translational Neuroscience of Southeast University Affiliated Nantong First People's Hospital, Southeast University, Jiangsu, 226014, China.
Yumin YangJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Jianhong ShenDepartment of Neurosurgery, Affiliated Hospital of Nantong University, Key Laboratory of Neural Regeneration, Nantong University, Nantong, 226001, China.
Aihua ShiKey Laboratory for Magnetic Medicine of Shaanxi Province, Xi'an, 710061, China.
Guicai LiJiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid repair and functional reconstruction of long-distance peripheral nerve injury (PNI) is an important clinical challenge, but existing therapeutic strategies are unable to go beyond autologous nerve grafts to meet the clinical needs. Anisotropic topology can regulate the migration direction of nerve fibers, and magnetized nerve cells can accelerate the nerve regeneration process by directional migration driven via exogenous magnetic field, but there are rare reports of anisotropic topologized nerve grafts loaded with magnetized nerve cells for long-distance peripheral nerve regeneration (PNR). This study reports an anisotropic topological ovalbumin (OVA) scaffold loaded with magnetically responsive nerve cells for the repair of long-distance PNI. Compared with traditional nerve scaffolds, this scaffold system can synergize the stimulating effect of an exogenous magnetic field and the oriented topological structure of the scaffold to accelerate nerve cells migration and nerve regeneration process via regulating PI3K, ERK, and Ca

Indexed as

Anisotropic topologyExogenous magnetic fieldLong-distance peripheral nerve regenerationMagnetically-responsive neuronal cellsNerve graft

Identifiers

PMID41282409
PMCPMC12637198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.