ArticleFrontiers in cardiovascular medicine2025
Relationship between trace elements status and atrial fibrillation in patients with valvular heart diseases.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Atrial fibrillation (AF) combined with valvular heart disease (VHD) is increasingly prevalent worldwide and is associated with high morbidity and mortality. Studies have showed trace element concentrations varied in patients with AF and may be involved in the pathogenesis of AF. However, no data is currently available for those with VHD. Methods: Urine samples as well as clinical data were collected from 72 VHD patients with AF (VHDAF) and 72 VHD patients without AF (VHD) and further analyzed for a panel of trace elements: lithium, manganese, cobalt, copper, zinc, arsenic, selenium, strontium, Cadmium, mercury, thallium, lead. Quantile g-computation was adopted to explore the joint effect of the 12 trace elements on AF in this population, and internal validation was performed using 1,000 bootstrap re-samples. Results: Compared with the VHD group, Sr levels were reduced, while Mn, Cu and Hg concentrations were increased in the VHDAF group. Quantile g-computation model indicated a significant association between the mixtures of the 12 urinary trace elements and AF in patients with heart valve disease (adjusted OR: 2.051; 95% CI: 1.180-3.565; Conclusion: VHDAF patients had higher Cu levels and lower Sr levels, and the two elements have been supposed to exert the largest influence on AF. Further research is needed to establish the causal relationships.
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