ReviewFrontiers in cardiovascular medicine2025
Heart rate variability: a multidimensional perspective from physiological marker to brain-heart axis disorders prediction.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07560800 (Effect of Beetroot Juice on Cardiovascular and Autonomic Responses During and After Exercise in Adults With Type 2 Diabetes), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Beetroot Juice on Cardiovascular and Autonomic Responses During and After Exercise in Adults With Type 2 Diabetes
Who cites it
10 citing papers in PubMed.
- Breathing Interventions Improve Autonomic Function, Respiratory Efficiency and Stress in Dysfunctional Breathing: A Randomised Controlled Trial.Advances in respiratory medicine · 2025Trial
- A Wearable-Derived Autonomic Component Is Associated with Cardiovascular Health in Community-Dwelling Adults: A Cross-Sectional Analysis from the Longevity Check-Up 8+ Study.Medical sciences (Basel, Switzerland) · 2026Article
- Predicting the Risk of Cardiovascular Diseases in the Elderly Based on Clinical Data and Heart Rate Variability Using Machine Learning.Journal of clinical medicine · 2026Article
- DFAα1 as an intensity-sensitive biomarker for exercise prescription: a prospective cross-sectional study in healthy young adults.European journal of applied physiology · 2026Article
- Acute Autonomic and Perceptual Responses to Resistance Training Performed With and Without Blood Flow Restriction.Journal of functional morphology and kinesiology · 2026Article
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
- Associations of Poincaré Plot-Derived Parameters with Heart Rate Variability and Autonomic Reflex Testing in a Real-World Clinical Population.Diagnostics (Basel, Switzerland) · 2026Article
- Decision-centered wearable biosensors for personalized rehabilitation: integrating multimodal monitoring, artificial intelligence, and closed-loop intervention.Frontiers in bioengineering and biotechnology · 2026Review
- Artificial intelligence in neurocardiology: decoding brain-heart network interactions for clinical and translational insights.Frontiers in neuroscience · 2026Review
- Pathophysiological frameworks and emerging preventative strategies in SUDEP.Frontiers in neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart rate variability (HRV), a non-invasive measure of autonomic nervous system (ANS) activity and homeodynamics, has received much attention in recent years in the study of cardiovascular disease, mental health, and aging. Changes in HRV not only reflect an individual's ability to adapt to changes in the internal and external environment but also correlate with a wide range of pathological states, making it a powerful tool for predicting disease risk and assessing the efficacy of treatment. The aim of this review is to comprehensively analyze the role of HRV in different physiological and pathological contexts and explore its value as a potential biomarker. Initially, we review the basic concepts, measurements, and influencing factors of HRV, followed by an in-depth discussion of the relationship between HRV and cardiovascular disease, epilepsy, depression, aging, and inflammation. Special emphasis is placed on the role of HRV in assessing the health impact of obesity, nutrition, and lifestyle. Additionally, we explore the use of HRV in clinical practice, including its potential in predicting disease, guiding treatment, and evaluating the effects of interventions. Ultimately, we suggest future research directions, including the promise of HRV in individualized medicine and health monitoring. While HRV holds promise as a non-invasive, trans-diagnostic biomarker, current evidence remains preliminary and largely associative. Its clinical utility for personalized medicine or routine risk prediction requires standardized acquisition protocols, external validation, and causal inference studies before implementation into decision-making algorithms. By synthesizing multiple studies through the lens of brain - heart axis (BHA) integrity, we propose that HRV metrics serve as a quantifiable, trans-diagnostic proxy for mapping the measurement, mechanistic, and translational axes of brain - heart dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.