ArticleFrontiers in endocrinology2025
Effect of maternal age, embryo number and quality on pregnancy outcome during frozen embryo transfer cycle.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Predictive value of serum β-hCG and blastocyst transfer for clinical pregnancy after frozen-thawed embryo transfer: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- A Retrospective Analysis of Pregnancy Outcomes Following Frozen Embryo Transfer in Patients With Persistent Chronic Endometritis: A Five-Year Single-Center Study.Immunity, inflammation and disease · 2026Article
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Authors and funding
11 authors.
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Abstract
Background: To investigate the effects of maternal age, the number of transferred embryos, and embryo quality on pregnancy-related outcomes in frozen-thawed embryo transfer cycles. Design: A retrospective cohort study was conducted on 1031 frozen-thawed embryo transfer cycles enrolled at our hospital from January 2015 to December 2021. Results: In the pregnant group, maternal age was significantly lower compared to the non-pregnant group; additionally, both the number of transferred embryos and the number of high-quality embryos transferred were significantly higher in the pregnant group. Women older than 35 years exhibited significantly lower clinical pregnancy rate (p < 0.05), implantation rate (p < 0.001), and live birth rate (p < 0.01). A higher number of transferred embryos was associated with significantly increased clinical pregnancy rate (p < 0.001) and live birth rates (p < 0.001). When transferring two embryos, higher numbers of 7-9 cell embryos (p < 0.01) and grade 1 embryos (p < 0.001) were positively correlated with improved clinical outcomes, while increased transfers of fragmented (p < 0.05) and uneven embryos (p < 0.05) were negatively associated with these outcomes. Conclusion: Maternal age, the number of transferred embryos, and embryo quality significantly influence pregnancy outcomes in frozen-thawed embryo transfer cycles. Clinicians should carefully tailor transfer plans based on individual patient characteristics and select optimal embryos for transfer to maximize success rate.
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