ArticleResearch square2025
Epithelial Hypusination Regulates Helicobacter pylori-induced Gastric Inflammation.
Alain P Gobert, Kara M McNamara, Caroline V Hawkins, Mohammad Asim, Daniel P Barry, Alberto G Delgado, Kristie L Rose, Purvi Patel, Regina N Tyree, Kate S Carson and 3 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Alain P GobertVanderbilt University Medical Center.
Kara M McNamaraVanderbilt University Medical Center.
Caroline V HawkinsVanderbilt University Medical Center.
Mohammad AsimVanderbilt University Medical Center.
Daniel P BarryVanderbilt University Medical Center.
Alberto G DelgadoVanderbilt University Medical Center.
Kristie L RoseVanderbilt University School of Medicine.
Purvi PatelVanderbilt University School of Medicine.
Regina N TyreeVanderbilt University Medical Center.
Kate S CarsonVanderbilt University Medical Center.
Lori A CoburnVanderbilt University Medical Center.
M Blanca PiazueloVanderbilt University Medical Center.
Keith T WilsonVanderbilt University Medical Center.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MRole of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Maria Blanca Piazuelo · 2009 to 2026
$27.5MProject 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8MMULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCERT32CA009592 · NCI · VANDERBILT UNIVERSITY · PI Justin M Balko, Julie A Rhoades (Sterling) · 1987 to 2026
$10.4MSpermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated CarcinogenesisR01DK128200 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2021 to 2024
$2.7MPolyamine Dysregulation in the Gastric Epithelium during Helicobacter pylori Infection and its Impact on Gastric CarcinogenesisF31CA278330 · NCI · VANDERBILT UNIVERSITY · PI MCNAMARA, KARA · 2023 to 2025
$72kBLRD VA I01 BX004366CSRD VA I01 CX002171CSRD VA I01 CX002473NCI NIH HHS F31 CA278330NCI NIH HHS P01 CA028842NCI NIH HHS P01 CA116087NCI NIH HHS P30 CA068485NCI NIH HHS T32 CA009592NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK128200
6 · The paper itselfAbstract
Hypusine is a unique amino acid synthesized on the eukaryotic initiation factor 5A (EIF5A) from the polyamine spermidine by deoxyhypusine synthase (DHPS). Hypusination of EIF5A plays a key role in translation. Here, we examined the contribution of the epithelial hypusination pathway to gastric inflammation induced by
Indexed as
GastritisHypusineInfectionPolyaminesProteome
Identifiers
PMID41282235
PMCPMC12637816
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