ArticleResearch square2025
Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.
Eleanor K O'Brien, Timothy Cox, Shane Fernandez, Pierrick Bourgeat, Tenielle Porter, Ben Goudey, James D Doecke, Colin L Masters, Jurgen Fripp, Kwangsik Nho and 6 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Eleanor K O'BrienEdith Cowan University.
Timothy CoxCommonwealth Scientific and Industrial Research Organisation.
Shane FernandezEdith Cowan University.
Pierrick BourgeatCommonwealth Scientific and Industrial Research Organisation.
Tenielle PorterEdith Cowan University.
Ben GoudeyUniversity of Melbourne.
James D DoeckeCommonwealth Scientific and Industrial Research Organisation.
Colin L MastersUniversity of Melbourne.
Jurgen FrippCommonwealth Scientific and Industrial Research Organisation.
Kwangsik NhoIndiana University School of Medicine.
Victor L VillemagneUniversity of Pittsburgh.
Carlos CruchagaWashington University.
Christopher C RoweAustin Health.
Andrew J SaykinIndiana University School of Medicine.
Vincent DoreCommonwealth Scientific and Industrial Research Organisation.
Simon M LawsEdith Cowan University.
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ARTHUR W TOGA · 2016 to 2026
$226.7MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MDemocratising Machine Learning for researchers working in Alzheimer's spaceR01AG058676 · NIA · UNIVERSITY OF MELBOURNE · PI MASTERS, COLIN · 2018 to 2022
$10.9MTHE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3MDRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4MNCATS NIH HHS UL1 TR000448NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG058676NIA NIH HHS U19 AG024904NIBIB NIH HHS R01 EB009352
6 · The paper itselfAbstract
Accumulation of brain amyloid beta (Aβ) is a key pathological hallmark of Alzheimer's disease (AD) and begins many years before cognitive symptoms. Being able to predict the risk of Aβ accumulation, or the age at which this accumulation exceeds a critical threshold, may enable early intervention and treatment to slow or prevent the onset of AD. We utilised published genome-wide association studies (GWAS) to develop polygenic scores (PGS) based on AD risk (PGS
Indexed as
age at onset of amyloid betaAlzheimer’s diseaseamyloid beta accumulationpolygenic scoresresiliencerisk
Identifiers
PMID41282187
PMCPMC12633517
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