ArticleResearch square2025
Optimization of injections with speculum-compatible devices to deliver ethyl cellulose-ethanol into the cervix to treat cervical dysplasia.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intracervical injections directly delivery therapies into the cervix. We previously explored ethyl cellulose (EC)-ethanol intracervical injections as a treatment for cervical dysplasia in low- and middle-income countries. Here we: 1) compared swine and human cervices to assess swine as a model for intracervical injections, and 2) evaluated two speculum-compatible injectors: a custom single needle injector and an extender injector, assembled from off-the-shelf components, to determine what parameters produced optimal distribution. Mechanical properties of swine and human cervices were compared. Swine cervices were injected with EC-ethanol iohexol using both injectors. Distribution and leakage volumes in tissue was visualized with microCT and quantified with 3D Slicer. Mechanical testing showed swine and human cervical tissue yielded comparable storage and loss moduli (p > 0.05).
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