ArticleResearch square2025
A psychobiological resilience factor for mental health across the lifespan.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
30 authors.
Funding
Abstract
Psychological resilience plays a crucial role in maintaining individual mental health in the face of stressful events, adversity, and even trauma. However, resilience, may be a dynamic and evolving process, which presents challenges for precise definition and measurement, particularly during the rapid developmental period of adolescence. In this study, we demonstrated that the self-reported ability to bounce back from adversity of middle-aged to older adults (UKB) can reflect their mental fortitude over a 16-year period. We then constructed a psychosocial model based on UKB to predict resilience from multi-level factors, such as personality traits, family-support, and economics. The model revealed that personality traits and life satisfaction accounted for the largest proportion of resilience variance. When applied prospectively to a longitudinal adolescent cohort (IMAGEN; n=692), this model accurately identified trauma-exposed adolescents who maintained mental health outcomes comparable to non-traumatised peers up to age 23. These findings demonstrate that psychosocial mechanisms stabilised in adulthood can predict adaptive functioning after early adversity, providing a lifespan framework for the early identification and prevention of mental health vulnerability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.