ArticleResearch square2025
Deconstruction of a spino-brain-spinal cord circuit drives chronic mechanical pain.
Qian Wang, Joo-Han Lee, Gregory Nachtrab, Yuan Yuan, Lei Yuan, Wei Qi, Manuel Alexander Mohr, Jing Xiong, Mark A Horowitz, Xiaoke Chen
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Qian WangDepartment of Biology, Stanford University; Stanford, California 94305, USA.
Joo-Han LeeDepartment of Biology, Stanford University; Stanford, California 94305, USA.
Gregory NachtrabDepartment of Biology, Stanford University; Stanford, California 94305, USA.
Lei YuanDepartment of Biology, Stanford University; Stanford, California 94305, USA.
Wei QiDepartment of Biology, Stanford University; Stanford, California 94305, USA.
Jing XiongDepartment of Electrical Engineering, Stanford University; Stanford, CA 94305, USA.
Mark A HorowitzDepartment of Electrical Engineering, Stanford University; Stanford, CA 94305, USA.
Funding
Molecular tools for precise manipulation of defined synaptic connectionsR01MH135934 · NIMH · STANFORD UNIVERSITY · PI Xiaoke Chen, IVAN SOLTESZ · 2024 to 2026
$4.0MMulti-modal profiling of spatially resolved cell types mediating opioid withdrawalR01DA059602 · NIDA · STANFORD UNIVERSITY · PI Bogdan Bintu, Xiaoke Chen · 2023 to 2026
$3.1MThalamic Circuits Underlying Opioid SeekingR01DA045664 · NIDA · STANFORD UNIVERSITY · PI CHEN, XIAOKE · 2018 to 2022
$2.3MThalamic Circuits for Prosocial Behaviors in MiceR01MH116904 · NIMH · STANFORD UNIVERSITY · PI CHEN, XIAOKE · 2019 to 2022
$1.8MRapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light sourceRF1NS126076 · NINDS · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM, CHEN, XIAOKE · 2022 to 2022
$1.8MCircuitry and Molecular Mechanisms for Descending Pain FacilitationR01NS129834 · NINDS · STANFORD UNIVERSITY · PI Xiaoke Chen · 2023 to 2026
$1.7MArousal circuitry and opiate-associated memoriesR01HL150566 · NHLBI · STANFORD UNIVERSITY · PI CHEN, XIAOKE, DE LECEA, LUIS · 2019 to 2019
$1.6MNHLBI NIH HHS R01 HL150566NIDA NIH HHS R01 DA045664NIDA NIH HHS R01 DA059602NIMH NIH HHS R01 MH116904NIMH NIH HHS R01 MH135934NINDS NIH HHS R01 NS129834NINDS NIH HHS RF1 NS126076
6 · The paper itselfAbstract
Inflammation or nerve injury at periphery can cause chronic pain. Although the spinal cord-projecting neurons in the rostral ventromedial medulla (RVM
Identifiers
PMID41282163
PMCPMC12633165
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