ArticleResearch square2025
MRI of ASCT2-mediated amino acid uptake in xenograft tumor models.
Behnaz Ghaemi, Balaji Krishnamachary, Natalie Dillman, Kirsten N Bains Williams, Yuki Hodo, Yuguo Li, Marie-France Penet Vidaver, Martin G Pomper, Caitlin M Tressler, Zaver M Bhujwalla and 4 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Behnaz GhaemiJohns Hopkins University.
Balaji KrishnamacharyJohns Hopkins University.
Natalie DillmanJohns Hopkins University.
Kirsten N Bains WilliamsJohns Hopkins University.
Yuki HodoJohns Hopkins University.
Yuguo LiKennedy Krieger Institute.
Marie-France Penet VidaverJohns Hopkins University.
Martin G PomperUniversity of Texas Southwestern Medical Center.
Caitlin M TresslerJohns Hopkins University.
Zaver M BhujwallaJohns Hopkins University.
Michael T McMahonKennedy Krieger Institute.
Jeff W M BulteJohns Hopkins University.
Peter C M ZijlJohns Hopkins University.
Aline M ThomasJohns Hopkins University.
Funding
Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff W. Bulte · 2017 to 2026
$11.8MSPORE in Prostate CancerP50CA272391 · NCI · JOHNS HOPKINS UNIVERSITY · PI Samuel R Denmeade, SHAWN LUPOLD · 2024 to 2026
$9.0MIntracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor TherapyR01EB030376 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2020 to 2024
$2.1MUpgrade of the 11.7T Research Scanner at the F.M. Kirby Research CenterS10OD032188 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2024 to 2024
$1.7MImaging Prostate Cancer Immune Evasion using Chemical Exchange Saturation Transfer MRIK01EB030612 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI THOMAS, ALINE · 2021 to 2024
$529kProstate cancer-diagnosing imaging agentsR21EB035705 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Aline Thomas · 2025 to 2026
$410kNCI NIH HHS P50 CA272391NIBIB NIH HHS K01 EB030612NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB030376NIBIB NIH HHS R21 EB035705NIH HHS S10 OD032188
6 · The paper itselfAbstract
We investigated alanine as a magnetic resonance imaging (MRI) biomarker for alanine-serine-cysteine transporter 2 (ASCT2), the primary transporter for glutamine in cancer. Alanine exhibited higher contrast using the chemical exchange saturation transfer (CEST) method than other major ASCT2 substrates. Upon bolus injection of alanine (6 mmole/kg), CEST MRI enhancement
Identifiers
PMID41282145
PMCPMC12633509
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