Evidence map›Paper›PMID 41282140›Full record

ArticleResearch square2025

The role of Themis in development of type 2 diabetes.

Nicholas Gascoigne, Lukasz Wojciech, Mukul Prasad, Joanna Brzostek, Vasily Rybakin, John Hoerter, Bowen Hou, Desmond Tung, Yen Leong Chua, Jeanette Ampudia and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicholas GascoigneImmunology Center of Georgia, Augusta University.ORCID https://orcid.org/0000-0001-9980-4225
Lukasz WojciechŁukasiewicz - PORT.
Mukul PrasadNational University of Singapore.
Joanna BrzostekNational University of Singapore.
Vasily RybakinNational University of Singapore.
John HoerterNovartis Biomedical Research.
Desmond TungNational University of Singapore.
Yen Leong ChuaNational University of Singapore.
Jeanette AmpudiaThe Scripps Research Institute.
Anooja RaiNational University of Singapore.
Grzegorz ChodaczekŁukasiewicz - PORT.
Guo FuXiamen University.
Sven PetterssonKarolinska Institutet.

Funding

Themis in Type II DiabetesR21DK094173 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI GASCOIGNE, NICHOLAS R · 2012 to 2013
$513k
NIDDK NIH HHS R21 DK094173
6 · The paper itself

Abstract

Type 2 diabetes (T2D) is a complex metabolic disorder driven by chronic inflammation and immune dysregulation, particularly within adipose tissue. This study investigates the role of the T cell-specific protein Themis in modulating immune-metabolic interactions that contribute to T2D pathogenesis. Using high-fat diet (HFD)-induced obesity models, we demonstrate that

Identifiers

PMID41282140
PMCPMC12637807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.