ArticleResearch square2025
HIV-1 Tat protein exposure alters the morphological characteristics and gene expression in the primary mouse cortex endothelial cells and human brain microvascular endothelial cells.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
HIV-1-associated neurocognitive disorders (HAND) are highly prevalent in the era of combination of antiretroviral therapies. Recent studies suggest that damage of blood-brain barrier (BBB) may serve as an early biomarker of cognitive dysfunction in people living with HIV. This is due to the ability of HIV-1, along with infected monocytes and macrophages, to traverse the BBB via either paracellular or transcellular way. HIV-1 viral proteins have been shown to disrupt tight junctions within the BBB, thereby directly compromising its structural and functional integrity. This study determined the effects of the HIV-1 transactivator of transcription (Tat) protein on the morphological profiles and gene expression of mouse prefrontal cortex endothelial cells (ECs) and human brain microvascular endothelial cells (HBMVEC). Both mouse ECs and HBMVEC were exposed
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