ArticleResearch square2025
Meta-sGWAS: Integrating brain spatial interactions to uncover genetic variants in Bipolar Disorder.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bipolar Disorder (BD) is influenced by both genetic factors and structural changes in brain regions, along with the impact of external environmental factors on brain network interactions. Conventional genome-wide association studies (GWAS) have identified genetic variants linked to BD but often overlook the spatial interactions and correlations in the brain. In this study, we introduced Spatial Genome-Wide Association Studies with Meta-analysis (Meta-sGWAS), a novel approach to decode the brain areas' interaction patterns and related genetic underpinnings. Based on the genomic and brain MRI datasets from Adolescent Brain Cognitive Development (ABCD) and the UK Biobank (UKB), Meta-sGWAS first revealed significant associations between brain ROIs and BD, as well as the interactions among these ROIs. Notably, the "Right-G_subcallosal" (
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