Evidence map›Paper›PMID 41282094›Full record

ArticleResearch square2025

Temporal dysregulation of

Shelli R Kesler, Kimberly A Lewis, Heather Cuevas, Elena Flowers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shelli R KeslerUniversity of Texas at Austin.
Kimberly A LewisUniversity of California Los Angeles.
Heather CuevasUniversity of Texas at Austin.
Elena FlowersUniversity of California.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Walter K. Kremers · 2019 to 2026
$33.5M
NIA NIH HHS P30 AG062677NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

Background: Type 2 diabetes mellitus (T2DM) is associated with increased risk for cognitive decline and diagnosis of Alzheimer's disease (AD). The mechanisms of T2DM related dementia remain unclear. Methods: Brain magnetic resonance imaging was retrospectively obtained for 1,802 adults (age 66 +/- 9 years, 47% male) of whom N = 271 had T2DM. We applied an accelerated longitudinal design and imaging transcriptomics to non-invasively examine the group-level trajectories of Results: Gene expression trajectories differed significantly between T2DM and controls (χ Conclusions: The convergence of

Indexed as

clinical dementia ratingcognitive declineimaging transcriptomicsmetforminmiRNA-20bMRItype 2 diabetes

Identifiers

PMID41282094
PMCPMC12633498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.