Evidence map›Paper›PMID 41282072›Full record

ArticleResearch square2025

CEBPB, C19MC, and Defective Autophagy Drive Novel Podosomal Belt to Macropinocytosis Transition, Lipid Accumulation, and HBV A-to-I RNA-editing.

Goodwin Jinesh, Nino Mtchedlidze, Varsha Devarapalli, Santanu Adhikary, John Lockhart, Marco Napoli, Isha Isha, Michelle Reiser, Ling Cen, Xiaoxian Liu and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Goodwin JineshMoffitt Cancer Center.ORCID https://orcid.org/0000-0002-2170-3245
Nino MtchedlidzeMoffitt Cancer Center.
Varsha DevarapalliMoffitt Cancer Center.
Santanu AdhikaryMoffitt Cancer Center.
John LockhartMoffitt Cancer Center.
Marco NapoliMoffitt Cancer Center.
Isha IshaSaveetha Medical College.
Michelle ReiserMoffitt Cancer Center.
Ling CenMoffitt Cancer Center.
Xiaoxian LiuMoffitt Cancer Center.
Sean YoderH. Lee Moffitt Cancer Center.
Tania MesaMoffitt Cancer Center.
Elsa FloresMoffitt Cancer Center.ORCID https://orcid.org/0000-0002-6173-2403
Andrew BrohlMoffitt Cancer Center.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Role of the Chromosome 19 MicroRNA Cluster in Liver CancersK08CA255933 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BROHL, ANDREW SCOTT · 2021 to 2023
$746k
NCI NIH HHS K08 CA255933NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

Obesity and neurodegeneration are clinically associated diseases with defective autophagy. However, the genetic, biological, and metabolic underpinnings connecting these diseases are not well-understood. Here we identified a Mitochondria

Indexed as

ADARC19MCCEBPB-LAPChloroquineCirrhosisDEPTORElectron Transport ChainHeminHepatitis-B virus (HBV)Lactic acidosisLipid dropletMacropinocytosismicro RNAsMitochondriamTORNDUFA3NICD: Notch1 intracellular domainNMD: Nonsense -mediated decayobesityOXPHOS: oxidative phosphorylationPodosomal beltQuinoneRedoxRNA-editingVacuole

Identifiers

PMID41282072
PMCPMC12636704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.