Evidence map›Paper›PMID 41282055›Full record

ArticleResearch square2025

Sequential Lymphotoxin Beta Receptor and Retinoic Acid Receptor signals regulate cDC2 fates.

Albert A Nguyen, Logan Fisher, Jennifer S Y Ahn, Michelle Zuo, Tyler Park, Anushka Yadav, Miki S Gams, Kei Haniuda, Dragos C Dasoveanu, Conglei Li and 11 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Albert A NguyenDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0001-8724-7476
Logan FisherImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences; New York, NY, USA.ORCID 0000-0003-4680-1527
Jennifer S Y AhnDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0009-0005-5305-8956
Michelle ZuoDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0002-6704-453X
Tyler ParkComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1246-1544
Anushka YadavImmune Oncology Program, Memorial Sloan Kettering Cancer Center; New York, NY, 10065 USA.ORCID 0000-0002-4333-6028
Miki S GamsDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.
Kei HaniudaDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0002-9313-6542
Dragos C DasoveanuDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.
Conglei LiDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.
Lesley A WardDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.
Angela A WangDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0001-6991-7368
Zakieh TayyebiComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7821-9905
Daria TrofimovaDepartment of Biomedical and Molecular Sciences, Queen's University.
Trevor McKeeDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0002-2195-6146
Cathy L MendelsohnDepartment of Pathology and Cell Biology, Columbia University.
John S AllinghamComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cynthia J GuidosDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0002-7674-2612
Blandine MaîtreDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.
Jennifer L GommermanDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. M5R 3C5.ORCID 0000-0003-4576-6168
Chrysothemis C BrownImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences; New York, NY, USA.ORCID 0000-0002-5834-926X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Acceptance of non-self: Decoding intestinal immune tolerance during early lifeDP2AI171116 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Chrysothemis Brown · 2022 to 2026
$2.7M
NCI NIH HHS P30 CA008748NIAID NIH HHS DP2 AI171116
6 · The paper itself

Abstract

Type II conventional dendritic cells (cDC2) are functionally and phenotypically heterogenous. Previous work in mice and humans identified two cDC2 subsets (cDC2A and cDC2B) and a monocytic DC3 subset. However, the microenvironmental cues governing their distinct differentiation pathways remain unclear. Here we delineate murine cDC2 lineage relationships and the sequential signals required for cDC2A maintenance. We show that cDC2s, arising from the CLEC9A

Identifiers

PMID41282055
PMCPMC12633193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.