Evidence map›Paper›PMID 41282053›Full record

ArticleResearch square2025

Effects of a Gain-of-Function Mutation in the Voltage-Gated Sodium Channel Gene, and of Dietary α-Linolenic Acid Supplementation, on Whole-Body Metabolism in Drosophila.

Karina Kruth, Junko Kasuya, Victoria Hand, Atulya Iyengar, Toshihiro Kitamoto

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Karina KruthUniversity of Iowa.
Junko KasuyaUniversity of Iowa.
Victoria HandUniversity of Alabama.
Atulya IyengarUniversity of Alabama.
Toshihiro KitamotoUniversity of Iowa.

Funding

Roles of hemocytes and bioactive lipids in the modulation of neuronal excitability and seizure behavior in Drosophila voltage-gated sodium channel mutantsR21NS127364 · NINDS · UNIVERSITY OF IOWA · PI KITAMOTO, TOSHIHIRO · 2022 to 2023
$425k
NINDS NIH HHS R21 NS127364
6 · The paper itself

Abstract

Epilepsy is a prevalent neurological disorder, and metabolic disturbances are increasingly recognized as key contributors to seizure susceptibility. We profiled whole-body metabolism in the precisely defined, seizure-prone

Indexed as

Dietary supplementationDrosophilaEpilepsyMetabolomicsω-3 Polyunsaturated fatty acid

Identifiers

PMID41282053
PMCPMC12633168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.