Trial reportMedical archives (Sarajevo, Bosnia and Herzegovina)2025
Silver Diamine Fluoride in Arresting Dental Caries Among Young Children: a Randomized Clinical Trial.
Trial report in Medical archives (Sarajevo, Bosnia and Herzegovina), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of graded prevention intervention combined with minimally invasive restoration on the oral health trajectory of caries-susceptible children.Frontiers in public health · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dental caries is a biofilm-mediated, sugar-driven disease in which acids from bacterial fermentation of dietary carbohydrates demineralize tooth structure. While early enamel lesions are reversible, progression into dentin allows rapid bacterial advancement toward the pulp due to the tissue's tubular structure. Objective: The primary objective of this study is to evaluate the effectiveness of SDF as a minimally invasive approach for arresting dental caries in young children. The secondary objective was to determine whether the alternating SDF+ FV regimen achieves higher caries arrest rates than SDF alone in uncooperative pediatric patients with early to moderate lesions. Methods: Study Design and Setting: This two-arm, parallel-group randomized controlled trial (RCT) was conducted in two private pediatric dental clinics in Tirana city center, Albania (directed by Dr. Manola Kelmendi and Dr. Enida Petro), both experienced in SDF use. The trial followed CONSORT guidelines, with single-blind outcome assessment, and ran from January 2021 to December 2022. Results: This randomized trial confirms that semiannual application of SDF is a highly effective and practical method for managing early and moderate caries in primary teeth, particularly in uncooperative children with ECC. Both protocols proved effective over two years. Alternating SDF with FV showed a modest additional benefit, though the difference did not reach statistical significance. Given their ease of application, low cost, and minimal invasiveness, SDF and SDF + FV remain valuable tools. Treatment success was strongly influenced by behavioral and social factors such as oral hygiene, sugar intake, and SES. Conclusion: This underscores the need for comprehensive caries risk assessment and highlights that SDF-based interventions should be combined with preventive education, dietary counseling, and improved hygiene resources to maximize effectiveness.
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Registered trials
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