ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2025
Association Between Glucose-related Protein 94 (GRP94) and Colorectal Cancer Location.
Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The incidence of chemotherapy-resistant colorectal cancer (CRC) is increasing. Location of CRC is important in determining CRC progression. The location itself is associated with the presence of cancer stem cell. Objective: The aim of this study is to determine association between GRP94 expression, a cancer stem cell marker, and location of CRC. Methods: This cross-sectional study was conducted in Adam Malik Hospital and it's sister hospitals. Inclusion criteria were patients who underwent colonoscopy or biopsy or operation due to CRC, Indonesian and willing to provide familial medical history regarding CRC and other malignancies up to third degree relatives. CRC tissue was obtained from each subject as specimen and undergone immunohistochemistry examination to determine GRP94 expression. Data was analyzed using statistical software. Results: A total of 118 subjects were involved and divided into proximal (32 subjects), distal (43 subjects), and rectal (43 subjects) CRC. Mean age of subjects was 57.30 (SD 12.99) years with 69 (58.5%) subjects were males. The percentage of high level GRP94 expression was found in subjects with distal CRC, folllowed by proximal and rectal CRC. There was a significant association between GRP94 expression and location of CRC (p=0.007). No relationship was observed between GRP94 expression with gender, age, body mass index, hemoglobin level, leukocyte count, platelet count, and histopathology grade of CRC. Conclusion: GRP94C expression is associated with the location of CRC. Higher GRP94 expression is observed in distal CRC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.