SynthesisFrontiers in medicine2025
Mechanical stress-mediated immune and inflammatory regulation:
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With advances in detection technologies and the trend of interdisciplinary integration, mechanical stress in biomechanics has been shown to exert broad effects on organisms. It influences multiple cellular processes, including proliferation, migration, and differentiation, and also plays a critical regulatory role in both immune cell function and the organismal immune-inflammatory response. Thus, an emerging interdisciplinary field-mechanoimmunology-has emerged. However, the specific mechanisms underlying this field remain incompletely elucidated. Herein, this study aims to identify the latest research hotspots and provide a thorough analysis of the current research status in this domain. Methods: A total of 1,901 articles were retrieved from the Web of Science Core Collection (WOSCC) and 2,954 articles from Scopus. These selected articles were imported into bibliometric analysis software for preliminary data processing, followed by further visual analysis using multiple graphing tools. Finally, specific analyses were conducted based on various categories, including journals, authors, geographical distribution, citations, and keywords. Results: The United States and China are the two leading research hubs in this field, with the University of California System currently standing as the most influential institution. A surge in research on mechanoimmunology has been observed since 2021. During the "Research Explosion Phase" post-2021, several new keyword clusters emerged, including "T cells," "macrophage polarization," and "ion channels," alongside clusters related to emerging fields such as "wound healing," "gut microbiota," and "bone remodeling." The mechanosensitive ion channel protein Piezo1 and the YAP/TAZ transcription complex in the Hippo pathway have emerged as key targets in recent studies. Conclusion: This study identifies the ongoing research surge in the field of mechanoimmunology while comprehensively delineating the current research landscape. Additionally, through keyword clustering across different phases, it uncovers the latest research hotspots and potential future research directions focused on novel mechanosensitive targets for immune-inflammatory modulation. This work provides a clear research roadmap for investigators in the field, offering insights into future research possibilities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.