ArticleFrontiers in medicine2025
Assessment of the risk of discontinuation of tenofovir disoproxil fumarate after delivery and the benefit of continued treatment in patients with immune tolerance.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Efficacy of pegylated interferon alpha in treating postpartum women with chronic hepatitis B virus infection: a multicenter prospective study.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
11 authors.
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Abstract
Background: Both domestic and foreign guidelines recommend that chronic hepatitis B virus (HBV) infection pregnant women in the immune tolerance phase (ITP) discontinue antiviral therapy after delivery, this study aimed to investigate the risk of postpartum drug withdrawal and the pros and cons of continuing treatment of tenofovir dipivoxil fumarate (TDF) in ITP pregnant women. Methods: The study group consisted of 116 naive pregnant women in ITP, the control group included 81 naive chronic hepatitis B (CHB) pregnant women with HBeAg-positive and high viral load. The study aimed to compare the risk of discontinue rebound within 48 weeks postpartum, the antiviral efficacy and bone and renal safety of continuing TDF treatment until 144 weeks postpartum between the two groups. Results: There was no significant difference in the reduction of HBV DNA levels between the ITP group and the CHB group prior to labor ( Conclusion: Postpartum discontinuation of TDF poses significant risks for immunotolerant pregnant women, whereas continuing TDF treatment for 144 weeks postpartum demonstrates favorable antiviral efficacy, bone and renal safety profiles.
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