SynthesisFrontiers in medicine2025
A systematic review and meta-analysis of the association between arterial carbon dioxide tension and patient outcomes after cardiac arrest.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Current international guidelines suggest that normocapnia should be targeted during the resuscitation phase following cardiac arrest. However, some studies propose that therapeutic hypercapnia might be a potential strategy to enhance cerebral perfusion and improve patient outcomes after cardiac arrest. However, few studies have explored the association between arterial carbon dioxide tension and the prognosis of patients after cardiac arrest. This systematic review and meta-analysis aims to evaluate the influence of arterial carbon dioxide tension on the prognosis of patients after cardiac arrest. Data sources: We searched MEDLINE, Embase, and Cochrane CENTRAL to identify studies that evaluated the association between the partial pressure of arterial carbon dioxide and outcomes after cardiac arrest. The primary outcome was the neurological status at the end of the follow-up period. The secondary outcomes included short-, mid-, and long-term mortality. The meta-analysis was conducted if statistical heterogeneity was low. Results: Twelve studies were included. Compared with normocapnia, hypercapnia was associated with lower in-hospital mortality (pooled OR 0.74, 95% CI 0.59-0.92). For neurological outcomes, hypercapnia was associated with less short favorable outcome (pooled OR 0.42, 95% CI 0.22-0.8). Conclusion: Among cardiac arrest patients, hypercapnia was associated with a reduction in in-hospital mortality and favorable neurological outcome compared to normocapnia. Systematic review registration: This systematic review was registered with PROSPERO (ID: CRD42025644636).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.