ArticleFrontiers in medicine2025
Influence of different urine preservation methods and addition of preservatives on quantitative detection of 24-h urinary protein.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to elucidate the effect of adding xylene as a preservative on 24-h urine protein quantification under different storage temperatures. Methods: From January 2020 to August 2020, our hospital selected a total of 80 samples with positive results of urine protein. Under different storage temperature conditions, urine samples containing or not containing xylene were collected simultaneously. Then, one-way analysis of variance was used to study the effects of preservatives and temperature on the 24-h urine protein quantification test. Receiver operating characteristic (ROC) analysis was used to examine the effect of adding preservatives on the accuracy of the 24-h urinary protein concentration determination. Results: Based on the results of the control group, there was no statistically significant difference in the 24-h urine protein concentration between the preservative group and the group without preservatives at 37, 24-26 or 4 °C ( Conclusion: Storing 24-h urine protein specimens at room temperature without using preservatives is a safe, simple, and feasible method. This method is suitable for wide application in clinical practice.
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