ArticleBioactive materials2026
Spatiotemporal evaluation of antithrombotic performance for biomaterials through monitoring β-sheet conformation changes at the blood interface.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombosis remains a critical challenge for blood-contacting medical devices, often resulting in device failure and potentially fatal complications. While various antithrombotic surfaces have been developed, the role of material-induced protein conformational changes in initiating coagulation is not fully understood. Here, we presented a Raman spectroscopy-based approach to monitor protein conformational changes during blood coagulation. An increase in β-sheet content was observed in both whole blood and plasma, which was attributed to fibrin polymerization. This β-sheet analysis was applied to evaluate heparin-mimicking polymer coatings (HMPCs) containing carboxylic and sulfonic acid groups. HMPCs with adequate polymer loading and an optimal carboxylic-to-sulfonic acid ratio prevented β-sheet elevation during recalcification and correlated with prolonged thrombin time. Raman mapping revealed spatially heterogenous β-sheet distribution on HMPC, delineating zones of effective antithrombotic performance. Collectively, Raman-based β-sheet analysis provides a spatiotemporal, in situ assessment of surface thrombogenicity, offering a valuable tool for guiding the design of nonthrombogenic biomaterials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.