ArticleBioactive materials2026
A self-locking conductive cardiac patch for immediate electrical integration with infarcted rat myocardium.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Financial Toxicity and Its Determinants in Cardiovascular Diseases: A Systematic Review and Bayesian Meta-Analysis.Inquiry : a journal of medical care organization, provision and financingPooled it
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- Mechanistic insights into andrographolide-mediated cardioprotective action through mitochondrial homeostasis: a network pharmacology and in vivo approach.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- AI-integrated nanomaterial-based biosensors for biomedical diagnostics: engineering design, signal processing, and clinical translation.Biomedical engineering online · 2026Review
- Repairing the Infarcted Heart: Preclinical Outcomes of Cardiac Tissue Engineering.Stem cell reviews and reports · 2026Review
- Mucin-Based Biomimetic Patches for Dynamic Heart Repair: Auxetic Structures and Translational Challenges.Cardiovascular engineering and technology · 2026Review
- A mechanically compliant MnORSC advances · 2026Article
- Heart disease diagnosis and categorization from ECG signals using hybrid Fuzzy-CNN machine optimized by meta-heuristic algorithms.Scientific reports · 2026Article
- Automatic Localization of Stable Highest Dominant Frequency Area in AF Patients Based on Spatial Aggregation.Bioengineering (Basel, Switzerland) · 2026Article
- Application of microneedle patches in the alleviation of cardiac infarction in animal models: a systematic review and meta-analysis.Journal of biological engineering · 2026Article
- KAN-DeScoD: Kolmogorov-Arnold Network Enhanced Deep Score-Based Diffusion Model for ECG Denoising.Sensors (Basel, Switzerland) · 2026Article
- Chitosan-based hydrogels for nitric oxide-mediated myocardial repair: advances and prospects.Journal of biological engineering · 2026Review
- Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis.Biomedicines · 2026Review
- Protective Role and Mechanism of Action of Garlic in Organ Ischemia-reperfusion Injury: Where do we Stand?Current medicinal chemistry · 2026Review
- Machine learning for prediction of newly diagnosed atrial fibrillation after emergency percutaneous coronary intervention during hospitalization in patients with acute ST-segment elevation myocardial infarction: a multi-center prospective study.Frontiers in medicine · 2026Article
- Nanomedicine for Cardiac Repair in Heart Failure: From Targeted Delivery to Regenerative Modulation.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial infarction (MI) is the leading cause of human death. Conductive patches have emerged as a promising alternative for MI repair. However, due to the epicardium and the scar tissue blocking the electrical connection between the patch and the myocardium, the immediate and effective electrical integration of the patch with the host myocardium remains a great challenge. Here, we report a conductive barbed microneedle-integrated conductive patch (CBMN-CP). The microneedle can not only self-anchor robustly to the myocardium, but also penetrate the epicardium into the inner myocardium enabling patch to bridge non-infarcted myocardium across the infarcted area immediately and to re-establish the electrical pathways in the infarcted myocardium. The rat MI model experiments demonstrated CBMN-CP significantly improved early cardiac function on day 3 post-infarction compared with traditional conductive patch. CBMN-CP enhanced myocardial repair efficacy by re-establishing intercellular electrical connections, promoting angiogenesis and regulating inflammatory responses. RNA sequencing showed that CBMN-CP mediated cardiac functions mainly through regulating early cardiac conduction and calcium handling-related gene expressions. Overall, the strategy of providing an immediate electrical integration through CBMN-CP demonstrated promising results and would be valuable in practical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.