Evidence map›Paper›PMID 41281796›Full record

ArticleInternational journal of hematology-oncology and stem cell research2025

A Rare Case of Bone Marrow Infiltration of Disseminated Medulloblastoma in a Young Adult.

Ruchee Khanna, Nithya Roopa Prem, Vishwapriya Mahadev Godkhindi, V Geeta

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Article in International journal of hematology-oncology and stem cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Ruchee KhannaDepartment of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Nithya Roopa PremDepartment of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Vishwapriya Mahadev GodkhindiDepartment of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
V GeetaDepartment of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma is the most common primary CNS malignant neoplasm in the paediatric age group, accounting for 12 to 20 % of all childhood malignancies, but medulloblastoma in an adult is rare. We report a case of a 31-year-old male who presented with an inability to walk and episodic vomiting. MRI of the brain revealed a midline lesion involving the vermis and cerebellar hemispheres. Excision and immunohistochemistry confirmed the diagnosis of medulloblastoma, desmoplastic/nodular. After 10 months, he had a recurrence of the tumour and a redo surgery was attempted, followed by 6 # cycles of chemotherapy. The patient was lost to follow-up; 3 years later, PET-CT showed multiple metastases to the lung and cervical lymph node along with bicytopenia. The bone marrow study revealed interstitial infiltration by small round blue cells. Immunohistochemistry showed these cells were positive for synaptophysin, supporting a diagnosis of medulloblastoma metastasis to the bone marrow.

Indexed as

Adult medulloblastomaBone marrowMetastasis

Identifiers

PMID41281796
PMCPMC12630538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.