ArticleInternational journal of chronic obstructive pulmonary disease2025
Appreciation of Increased Pulmonary Vascular Resistance from the Maximum Desaturation in 2-Chair Test: An Appraisal.
Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The desat max of 2-chair test, claimed to have identified the sildenafil responsiveness in COPD-PH (pulmonary hypertension), should represent high PVR (pulmonary vascular resistance). Methods: Hemodynamically diagnosed PH in CLD (chronic lung disease)-patients were analyzed statistically and divided into two groups on high or low PVR (>2 and ≤2 Wood units) to judge the power of the desat-max of 2-chair test differentiating them. Co-relationship of desat-max was sought with different spirometric, Doppler-echocardiographic, and RHC (right heart catheterization) derived parameters as TPG (trans-pulmonary gradient), PVR, mPAP (mean pulmonary pressure) and PCWP (pulmonary capillary wedge pressure). Further, the specificity and sensitivity of variable desat-max values were calculated and high PVR and a VIP plot was drawn with all available variables to see their impact on PVR compared to desat-max. Results: We included 57 patients of CLD-PH consisting of COPD (n=26), chronic asthma (n=9), ILD (n=7), and miscellaneous diseases (n=15). When divided on high or low PVR, the two groups (n=39 and 18) stood similar in demographic, spirometric, and Doppler-echocardiography measurements. However, they differed in desat-max (-8.76±4.90 and -3.61±1.94; Conclusion: Desat-max of 2-chair test appears indicative of high PVR in CLD-PH. The revelation merits further research.
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