Evidence map›Paper›PMID 41281759›Full record

ArticleInternational journal of biological sciences2025

How relevant is the mouse model for understanding human sex determination?

Francisco Brito, Chloé Mayère, Aurélie Lardenois, Violaine Regard, Sylwia Czukiewska, Cyril Djari, Pauline Sararols, Yasmine Neirijnck, Françoise Kühne, Séverine Mazaud-Guittot and 4 more

Abstract read
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In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francisco BritoDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Chloé MayèreDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Aurélie LardenoisUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes F-35000, France.
Violaine RegardDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Sylwia CzukiewskaDepartment of Anatomy and Embryology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Cyril DjariDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Pauline SararolsDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Yasmine NeirijnckDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Françoise KühneDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.
Séverine Mazaud-GuittotUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes F-35000, France.
Susana M Chuva de Sousa LopesDepartment of Anatomy and Embryology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Frédéric ChalmelUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes F-35000, France.
Antoine D RollandUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes F-35000, France.
Serge NefDepartment of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland.

Funding

European Research Council
6 · The paper itself

Abstract

The mouse is the most widely used model organism for studying mammalian gonadal sex determination and related human disorders. However, a systematic and comprehensive comparison of human and mouse sex determination processes is lacking. Here, we performed an interspecies comparative analysis of the single-cell transcriptomic atlas of gonadal sex determination in mice and humans. Our results revealed major transcriptomic differences in each of the major cell types between human and mouse gonads. Only a small fraction of these genes shared a comparable expression profile, often genes known to be essential for gonadal sex determination. While the most differentiated gonadal cell types share similar transcriptomic signatures between humans and mice, poorly differentiated cells, such as somatic progenitors, show more divergent profiles. Ultimately, these comparisons will identify the genes and pathways for which the mouse is a suitable model to study human gonadal abnormalities and optimise the use of animal models.

Indexed as

Sex Determination ProcessesAnimalsFemaleGene Expression ProfilingGonadsHumansMaleMiceModels, AnimalTranscriptomegerm cellsgonadal sex determinationhumanLeydig cellsmouseovarypre-granulosa cellsSertoli cellssingle-cell transcriptomictestis

Identifiers

PMID41281759
PMCPMC12631067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.