Evidence map›Paper›PMID 41281718›Full record

ArticleEnvironmental epigenetics2025

Early-life exposure to secondhand smoke and polycyclic aromatic hydrocarbons: associations with epigenetic aging among children.

Sneha S Patil, Anne K Bozack, Ajay Pillarisetti, Smita S Patil, Kyle Steenland, Kalpana Balakrishnan, Lance A Waller, Shirin Jabbarzadeh, Jennifer Peel, Thomas F Clasen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sneha S PatilDepartment of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, TN 600116, India.ORCID https://orcid.org/0000-0001-6698-2711
Anne K BozackDepartment of Population Health, NYU Grossman School of Medicine, New York, NY 10016, United States.
Ajay PillarisettiDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94704, United States.
Smita S PatilGeneral Physician, Private Practitioner, Pune, MH 411006, India.
Kyle SteenlandGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Kalpana BalakrishnanDepartment of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, TN 600116, India.
Lance A WallerDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.ORCID https://orcid.org/0000-0001-5002-8886
Shirin JabbarzadehDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Jennifer PeelDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States.
Thomas F ClasenGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Dana Boyd BarrGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Naveen PuttaswamyDepartment of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, TN 600116, India.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA 94305, United States.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
FIC NIH HHS D43 TW010540NIEHS NIH HHS R01 ES031259
6 · The paper itself

Abstract

Epigenetic clocks are valuable tools for assessing biological age. Exposure to secondhand smoke (SHS) and polycyclic aromatic hydrocarbons (PAHs) has been linked with epigenetic age deviation (EAD) in adults. However, associations in children remain largely unexplored. We investigated relationships between exposure-spanning prenatal, early postnatal, current (36-60 months, time of sample collection) periods-and EAD in preschool-aged children. DNA methylation was measured in buccal cells from 43 children (mean age: 4.1 years) in the CAries Risk from exposure to Environmental tobacco Smoke-Household Air Pollution Intervention Network cohort. SHS exposure was assessed using urinary cotinine and 3-hydroxycotinine (3-HC), while PAHs exposure was assessed via urinary 2-naphthol (2-NAP) and 1-hydroxypyrene (1-PYR). Nicotine equivalents were calculated as molar sum of cotinine + 3-HC. EAD was estimated using Horvath, Skin&Blood, Pediatric Buccal Epigenetic (PedBE), and DNA methylation-based telomere length (DNAmTL) clocks. Associations between exposures and EAD were evaluated using linear regression, adjusting for study site, mother's education, child's body mass index

Indexed as

childrenepigenetic agingepigeneticspolycyclic aromatic hydrocarbonssecondhand smoke

Identifiers

PMID41281718
PMCPMC12631029

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.