Evidence map›Paper›PMID 41281657›Full record

ArticleMaterials today. Bio2025

Overcoming chemoresistance via NO-mediated HSP inhibition using hybrid membrane-coated multifunctional nanoplatforms.

Maierhaba Aili, Fangrui Lin, Yu Chen, Nuernisha Alifu, Rong Ma, Chenyang Chu, Jiabao Xiong, Yaqi Cui, Zhong Du, Cailing Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maierhaba AiliState Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Fangrui LinCollege of Physics and Optoelectronic Engineering, State Key Laboratory of Radio Frequency Heterogeneous Integration (Shenzhen University), and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, 518060, China.
Yu ChenState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China.
Nuernisha AlifuThe Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi, 830054, China.
Rong MaState Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Chenyang ChuState Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Jiabao XiongThe Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi, 830054, China.
Yaqi CuiState Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
Zhong DuThe Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi, 830054, China.
Cailing MaState Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Biao DongState Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
Junle QuState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy resistance and the precise delivery as well as controlled release of drugs at tumor sites remain major challenges in cancer treatment. Heat shock proteins (HSPs) have been identified as key contributors to chemotherapy resistance, yet effective strategies to overcome this issue are still lacking. In this study, we developed a hybrid biomimetic nanoparticle system (CuS-PTX-ICG-L-arg@HR) that integrates photothermal therapy (PTT), chemotherapy, and gas therapy to enhance the efficiency of cervical cancer treatment. By fusing the red blood cell membranes with

Indexed as

CuSHSPsHybrid membranePaclitaxelTargeted therapy

Identifiers

PMID41281657
PMCPMC12637075

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.